Seek medical advice promptly if your cough is associated with: Shortness of breath or difficulty breathing (may indicate respiratory infection, heart failure, or allergic reaction) Chest pain or tightness (requires urgent assessment to exclude cardiac causes) Fever, night sweats, or unexplained weight loss (may suggest infection or other systemic illness) Coughing up blood (haemoptysis) (always requires immediate medical evaluation) Persistent hoarseness or voice changes (may indicate laryngeal pathology) Symptoms of severe allergic reaction (facial swelling, rash, wheezing, or difficulty swallowing) Call 999 or attend A&E immediately if you experience: Severe allergic reaction (anaphylaxis) with breathing difficulties, severe facial swelling, or collapse Severe chest pain Severe breathlessness Significant haemoptysis (coughing up large amounts of blood) British Thoracic Society guidance on the assessment of chronic cough (lasting more than 8 weeks) recommends a systematic approach to identify the underlying cause
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Based on results from the SURMOUNT-OSA trial, investigating tirzepatide in OSA patients with obesity, Eli Lilly submitted a supplemental new drug application to the FDA in June seeking approval for OSA
However, the substantially better efficacy (concerning HbA 1c and BW reductions) compared to semaglutide at the standard dose used in most type 2 T2D trials was the most remarkable finding (85, 86)
